Further highlighting the central role of proficient mitophagy in cardiac homeostasis, cardiomyocyte‐specific ablation of the gene encoding the PRKN regulator MFN2 (mitofusin 2) phenotypically manifests as lethal cardiomyopathy associated with insufficient mitophagy (Chen & Dorn, 2013), and co‐deletion of Mfn1 and Mfn2 in adult cardiomyocytes compromises optimal mitochondrial fusion, igniting dilated cardiomyopathy and heart failure (Hall et al, 2016). The gene discussed is MFN2; the disease is heart failure.