TG2 loss of function correlates with a defect in the nuclear translocation of HSF1 and restores the imbalance in the HSF1‐HSPA/HSP70 pathway in CF leading to an increase in approximately 40% in CFTR function in a CF mouse model lacking TGM2 (Rossin et al, 2018). The gene discussed is TGM2; the disease is cystic fibrosis.