The strict nexus between ALS and autophagy is further strengthened by experimental evidence indicating that genetic deletion of central (e.g., VCP) (Johnson et al, 2010) or ancillary regulators of the autophagic cascade (e.g., GRN/progranulin, ALS2/alsin‐2) precipitate ALS symptomatology in mice and human patients (Yang et al, 2001; Chang et al, 2017). Here, GRN is linked to amyotrophic lateral sclerosis.