Recently, a possible correlation between selective lysosomal degradation of ferritin (known as “ferritinophagy”) and COPD has emerged, suggesting that NCOA4 (nuclear receptor coactivator 4)‐dependent ferritinophagy occurring upon CS exposure accelerates COPD progression by instigating parenchymal lung cell ferroptosis (Yoshida et al, 2019). This evidence concerns the gene NCOA4 and chronic obstructive pulmonary disease.