Mutations in the gene coding for SQSTM1/p62 have been found in approximately 10% of PDB patients, and a mouse model carrying the P394L mutation exhibits a PDB‐like bone disorder with focal bone lesions, linked to enhanced autophagy activation in osteoclasts and detrimental bone remodeling (Hiruma et al, 2008). This evidence concerns the gene SQSTM1 and bone disorder.