CTSD and glomerular disorder: Importantly, disturbance of the autophagy flux in podocytes, by podocyte‐specific deletion of Atg5 (Hartleben et al, 2010), Pik3c3/Vps34 (Bechtel et al, 2013), or Ctsd (cathepsin D) (Yamamoto‐Nonaka et al, 2016), underpins events of glomerulosclerosis and proteinuria, culminating in severe glomerulopathy and kidney dysfunction.