As an example, conditional deletion of the gene coding for the ULK1/Atg1 interactor RB1CC1/FIP200 in mammalian epithelial cells restrains the growth of mammary carcinoma tumors induced by polyomavirus middle T antigen, associated with the induction of a prominent type I IFN response (Wei et al, 2011). The gene discussed is ULK1; the disease is breast carcinoma.