Indeed, a systemic partial autophagy defect, as observed in Atg4b‐deficient mice, predisposes to diet‐induced obesity (Fernandez et al, 2017), and obesity is associated with increased plasma levels of autophagy‐inhibitory factors including DBI/ACBP, both in humans and in mice (Bravo‐San Pedro et al, 2019; Joseph et al, 2020). Here, ATG4B is linked to obesity due to melanocortin 4 receptor deficiency.