While these experimental lines of evidence emphasize the positive role of autophagy in the regulation of β‐cell homeostasis, it is worth mentioning that constitutive activation of autophagy, by the expression of the knock‐in Becn1F121A dominant mutant, produces the paradoxical outcomes in the context of diet‐induced T2D of reducing glucose tolerance (due to the uncontrolled degradation of insulin granules) yet improving the responsiveness to insulin in peripheral tissues (Yamamoto et al, 2018). Here, INS is linked to type 2 diabetes mellitus.