INS and metabolic dysfunction-associated steatohepatitis: De facto, sustained nutritional imbalance over time and aberrant activation of the insulin signaling route abrogates the autophagic flux in the liver, leading to the onset of NAFLD, whose clinical manifestations span from non‐alcoholic steatosis to fibrosing non‐alcoholic steatohepatitis (NASH) (Allaire et al, 2019).