As recently revealed by multilayer brain proteomics analysis performed at different stages of AD in humans, the autophagic substrate SQSTM1/p62 (sequestosome 1) accumulates in AD, suggestive of impaired autophagic flux (Bai et al, 2020) similar to the one reported in AD experimental models (Yu et al, 2005). Here, SQSTM1 is linked to Alzheimer disease.