CRYAB and heart failure: Similarly, the overexpression of ATG7 ameliorates signs of DES (desmin)‐related cardiomyopathy in mice expressing the R120G mutant of CRYAB (crystallin, alpha B) (Bhuiyan et al, 2013), whereas the heterozygous loss of Becn1 accelerates heart failure under the same pathological setting (Tannous et al, 2008).