ATG5 and Hepatic fibrosis: In this respect, a proficient autophagy flux is required for the transdifferentiation of hepatic stellate cells into extracellular matrix‐producing myofibroblasts, as illustrated by the fact that hepatic stellate cell‐specific ablation of Atg5 protects mice from hepatic fibrosis induced by carbon tetrachloride (Thoen et al, 2011; Hernandez‐Gea et al, 2012).