Thus, the genetic knockout of the muscle‐specific ubiquitin ligase Fbxo32/atrogin‐1 (F‐box protein 32) prevents the proteasomal degradation of the autophagy regulator CHMP2B, possibly resulting in insufficient autophagic flux and aberrant protein aggregation, which are etiologically associated with the development of severe cardiomyopathy (Zaglia et al, 2014). This evidence concerns the gene FBXO32 and cardiomyopathy.