Overexpression of SNAI1, TWIST1, and ZEB1 in breast cancer is sufficient to increase the CD44+/CD24lo stem cell pool, resulting in increased sphere forming capacity in vitro, as well as elevated tumorigenicity and metastasis in vivo (Mani et al, 2008; Morel et al, 2008). The gene discussed is SNAI1; the disease is breast carcinoma.