LGR5 and neoplasm: Interestingly, LGR5 expression and WNT activity are crucial for disease progression, induction of EMT, stemness and metastasis, which is not provided by LGR5‐negative tumor cells and depletion of Lgr5+ cells in mice blocks metastasis (de Sousa e Melo et al, 2017), though a Lgr5‐ state is detected in circulating CSCs (Fumagalli et al, 2020).