ATM and breast carcinoma: In breast cancer cells, ZEB1 promotes radioprotection by driving the expression of the apical DDR kinase ATM via complex formation with p300 and PCAF at the ATM promoter as well as by stabilizing the mediator kinase CHK1 via sequestration of its deubiquitinase USP7 (Zhang et al, 2014; Zhang et al, 2018).