TGFB1 and neoplasm: During tumor initiation, TGFβ promotes differentiation, cell cycle arrest, senescence and apoptosis in pre‐malignant epithelial cells whereas during later stages TGFβ acts as inducer of EMT and promotes metastasis (Massague, 2012; Seoane & Gomis, 2017; Ramachandran et al, 2018; Derynck et al, 2021; Liu et al, 2021) (Fig 4A).