LRG1 and cancer: Leucine-rich alpha-2 glycoprotein-1 (LRG1) is a secreted glycoprotein which is commonly induced in pathological lesions where, amongst other properties, it promotes dysfunctional vessel growth.19,20 LRG1 contributes to pathological angiogenesis by corrupting the homeostatic influence of TGFβ signalling,20 and promotes vessel dysfunction by interfering with vessel stabilisation and maturation.21 Increasingly, therefore, LRG1 is seen as an important factor in determining vessel abnormality in a wide range of diseases, including cancer.