We also report that upon binding to the novel target LRG1 in the tumour environment, the ADC liberates its cytotoxic payload and shows, in vivo, enhanced tumour activity relative to antibody alone and similar anti-tumour activity when compared against the maximum tolerated dose of the chemotherapeutic agent cisplatin but crucially without any undesired side-effects and with scope for higher/more frequent dosage of the ADC to gain further efficacy in future studies. Here, LRG1 is linked to neoplasm.