The conformation of the polypeptide has been found to be markedly affected in the presence of lipid membranes and cosolutes.4–7 The toxic aggregated form of α-Syn detected in PD affected brain as well as other amyloidogenic proteins, such as the prion protein (PrP), have a high propensity to interact also with DNA.3,8–12 Therefore, studying the conformation of DNAs in the presence of α-Syn has immense importance because the interaction with α-Syn forms can significantly affect DNA replication and transcription along with causing DNA damage. The gene discussed is PRNP; the disease is Parkinson disease.