Inhibition of HR proteins can lead to radio- and genotoxic chemosensitivity,169,210 while synthetic lethal relationships of HR genes also exist that can be exploited for cancer treatment.97,98 HR has also been reported to facilitate resistance to alkylating therapy in glioblastoma cells more so than NHEJ.211 Together, this opens multiple avenues for targeting HR proteins for cancer therapy. The gene discussed is HR; the disease is cancer.