EPZ005687 displayed potent, selective reduction of H3K27me2/3 (IC50 = 80 nM) in cells196 and led to cell death in lymphoma lines bearing EZH2 Tyr641 and Ala677 mutations, with an IC50s of 300–400 nM across Tyr641 mutant cell lines. This evidence concerns the gene EZH2 and lymphoma.