DOT1L and cancer: In contrast to H3K79 methylation by DOT1L, H3K9 mono- and dimethylation by G9a and the closely related G9a like protein (GLP) is largely involved in the repression of transcription.150–152 The overexpression of G9a and GLP has been implicated in the progression of a variety of human cancers,153–155 along with addiction,156 neurodevelopmental disorders,157 viral infection,158 and peripheral neuropathy.