It was selective up to 50 μM against 20 HMTs and DNA (cytosine-5)-methyltransferase 1 (DNMT1), and reduced H3K9me2 levels in PC3 cells by 50% after dosing at 3 μM for 72 hours.169 It was also shown to induce modest (45%) tumour growth inhibition in a mouse xenograft model of AML, after 30 mg kg−1 dosing for two weeks.170. This evidence concerns the gene DNMT1 and acute myeloid leukemia.