PFI-1 induced growth inhibition and apoptosis in a dose-dependent manner in leukaemia cells,74 and also downregulated Aurora B kinase expression, which is implicated in a number of cancers, including leukaemia.75 It displayed poor PK properties in rats, with poor oral bioavailability, high clearance, and a short half-life. Here, AURKB is linked to leukemia.