Follow up analysis demonstrated that NR0B1 expression was associated with KEAP1 mutational status, and that covalent inhibitor targeting Cys247 inhibited anchorage-independent NSCLC cell growth.60 Very recently, they further investigated ligandability of cysteines in primary human T cells using a similar electrophilic “scout fragment” strategy.61 This work generated a view of cell-state dependent ligandable cysteines in human T cells, and the study further suggested that immunomodulatory compounds can be obtained rapidly via elaboration of electrophilic compounds. Here, KEAP1 is linked to non-small cell lung carcinoma.