Ibrutinib, developed as a covalent BTK inhibitor, has been approved by the FDA for the treatment of chronic lymphocytic leukemia, mantle cell leukemia (MCL) and Waldenström macroglobulinemia and is currently in multiple clinical trials because it has proved efficacy in different indications, such as non-small cell lung cancer and autoimmune diseases.7,47,48 With a broad selectivity profile, Ibrutinib inhibits the whole TEC family, EGFR, JAK3, Her2, Blk and Itk kinases. This evidence concerns the gene BLK and Waldenstrom macroglobulinemia.