In addition, despite the fact that TRAAK, a related two-pore-domain potassium (K2P) channel, is also modulated by ML67-33 (Bagriantsev et al., 2013), Trek1−/−-Trek2−/− mice did not restore from ISDN-induce mechanical allodynia, ruling out TRAAK participation in migraine pain. Here, KCNK4 is linked to migraine disorder.