The direct causality linking TRESK-MT to migraine was recently demonstrated by showing that using CRISPR-Cas9 to fix the MT mutation restores a normal nociceptor excitability (Pettingill et al., 2019) and that the TRESK-MT mutation generated altered proteins which affect TREK1 and TREK2 channel function. The gene discussed is MCAT; the disease is migraine disorder.