Surprisingly, NAKα3 was also later reported to serve as a toxic target of misfolded protein assemblies, such as α-synucleins, superoxide dismutase 1 (SOD1), and tau, leading to other neurodegenerative diseases such as Parkinson'’s disease and amyotrophic lateral sclerosis (ALS) (Ruegsegger et al., 2016; Shrivastava et al., 2015, 2019). Here, MAPT is linked to amyotrophic lateral sclerosis.