The expression of FCGR3B in monocytes treated with conditioned medium from spike protein stimulated NHBE of obese subjects was significantly higher than in non-obese subjects (p = 0.006), suggesting FCGR3B as a potential modulator of COVID-19 severity in patients with obesity (Figure S15, Tables S6, S7, S8). Here, FCGR3B is linked to obesity due to melanocortin 4 receptor deficiency.