FCGR3B and macrophage activation syndrome: Based on the abundance of FCGR3B upregulated MoAMs, it is possible that dysregulated macrophage response to SARS-CoV-2 infections may promote injury to the host tissue due to macrophage activation syndrome (Merad and Martin, 2020) or serve as a Trojan horse, enabling specific viral anchoring to the pulmonary parenchyma (Abassi et al., 2020).