SHBG: Sex hormone-binding globulin, BMI: Body mass index, FSH: Follicle-stimulating hormone, TSH: Thyroid-stimulating hormone, LH: Luteinizing hormone, DHEAS: Dehydroepiandrosterone sulfate, FBS: Fasting blood sugar, FI: Fasting insulin, HOMA-IR: Homeostasis model assessment of insulin resistance, QUICKI: Quantitative insulin-sensitivity check index, CI: Confidence interval. All data are presented as Mean ± SD. *P-value < 0.05 is considered significantly different using independent sample t test. ♦IQR: Interquartile range. The gene discussed is PLOD1; the disease is Insulin resistance.