A few diagnostic markers for specific tumors are available: Prostate specific antigen (PSA) for prostate cancer, Cancer antigen 125 (CA125) for ovarian cancer, calcitonin for medullary thyroid cancer, alpha fetoprotein (AFP) for liver cancer, and human chorionic gonadotropin (HCG) for germ cell tumors. This evidence concerns the gene MUC16 and Familial prostate cancer.