Almost all the DEPs upregulated in RA patients are involved in staphylococcus aureus infection, NF-kappa B signaling pathway, phagosome, PI3K/Akt signaling pathway, tuberculosis, natural killer cell-mediated cytotoxicity, B cell receptor signaling pathway, systemic lupus erythematosus (SLE), autoimmune thyroid disease (AITD), RA, and other inflammation and immune-related pathways. Here, AKT1 is linked to autoimmune thyroid disease.