As increased glucose uptake would lead to higher glucose oxidation, we interrogated the expression glucose transporters (Slc2a1, Slc2a4), the concentration of blood glucose, and the glycogen content in liver and small intestine, and the results showed that the glucose uptake was comparable between the WT and F3-KO mice during cardiac hypertrophy (Figures 5A,B; Supplementary Figures 7D,E). The gene discussed is SLC2A1; the disease is cardiac hypertrophy.