Haplotype analysis showed that the SYTL3-SLC22A3 A-C-A-A-A-A, G-T-C-G-C-A and A-T-A-A-C-A haplotypes increased the risk of CAD, while the SYTL3-SLC22A3 A-C-A-A-C-G haplotype reduced the risk of CAD. The gene discussed is SLC22A3; the disease is coronary artery disorder.