The SYTL3-SLC22A3 A-C-A-A-A-A (adjusted OR = 2.19, 95% CI = 1.49–3.21, P = 1E-04), G-T-C-G-C-A (adjusted OR = 1.82, 95% CI = 1.07–3.10, P = 0.026) and A-T-A-A-C-A (adjusted OR = 2.04, 95% CI = 1.14–3.66, P = 0.016) haplotypes increased the risk of CAD, while the SYTL3-SLC22A3 A-C-A-A-C-G (adjusted OR = 0.52, 95% CI = 0.34–0.78, P = 0.0016) haplotype reduced the risk of CAD. The gene discussed is SLC22A3; the disease is coronary artery disorder.