11 proteins matched with inflammatory-related GO:BP, including A2M (Alpha-2-Macroglobulin), C3 (Complement C3) were increased in samples with more severe MR, which were opposite to CAPZA1 (CapZ Alpha-1), CFL1 (Cofilin 1), CD44, F12 (Coagulation Factor XII), GSTP1, HMGB1 (High Mobility Group Box 1), PRDX5 (Peroxiredoxin 5), PSME1 (Proteasome Activator Subunit 1), S100A13 (S100 Calcium Binding Protein A13), which were decreased. Here, HMGB1 is linked to miotic rate.