We further explored the effect of regulator expression on cancer survival and found that high expression of TMPRSS2 in ACC; ACE1 in UVM and LUSC; AGTR2 in KIRP, KICH, and LUSC; ACE2 in LGG; and AGT in UVM were associated with poor survival of cancer patients, while expression of TMPRSS2 in KIRP, KICH, PAAD, and LIHC; ACE1 in KIRC, LIHC, and OV; SLC6A19 in KIRC, KIRP, and ESCA; ACE2 in KIRC and UVM; and AGT in PAAD were associated with good survival in cancer patients (Figure 1C and Supplementary Figure 1; p <0.05). The gene discussed is ACE; the disease is pancreatic adenocarcinoma.