Prognosis analysis showed that hypermethylation of AGTR2 in BRCA; AGT in SKCM, CESC, and LAML; TMPRSS2 in KIRP, LUAD, READ, ACC, and HNSC; SLC6A19 in KIRP; ACE2 in ACC; and ACE1 in HNSC were associated with poor survival. The gene discussed is TMPRSS2; the disease is reading.