ACE2 in BRCA, ACE1 in LUSC and BLCA, ACE2 and SLC6A19 in KIRC, AGT and AGTR2 in STAD, ACE2 and TMPRSS2 in LUAD, and TMPRSS2 in HNSC were the main regulator subtypes. The gene discussed is AGT; the disease is bladder transitional cell carcinoma.