CDH1 and cancer: The EMT program, naturally inducing a phenotypic switch during embryonic development or adult tissue homeostasis by the transcriptional repression of epithelial factors, such as E-cadherin (CDH1 gene), may be expressed during tumorigenesis to confer epithelial-to-mesenchymal plasticity to cancer cells, which then acquire stem-like properties (Ye and Weinberg, 2015; Brabletz et al., 2018; Stemmler et al., 2019).