TP53 and head and neck squamous cell carcinoma: Cisplatin has been reported to induce cellular senescent-like growth arrest in nasopharyngeal carcinoma cell line, and senescence is the primary mechanism by which cisplatin induces wild-type TP53 head and neck squamous cell carcinoma cell responses (Gadhikar et al., 2013; Osman et al., 2015).