• limb development • wound healing • tumor growth • NAA15: encodes a component of the Nat A Nacetyl-transferase complex, which tethering the complex to the ribosome for posttranslational modification of proteins • SMAD1: development of pulmonary hypertension • HHIP: development of lung malformation. The gene discussed is NAA15; the disease is pulmonary arterial hypertension.