Lewy pathology consists of insoluble misfolded α-synuclein that can be found in certain regions of the central and peripheral nervous system in PD (Wakabayashi et al., 1989; Spillantini et al., 1997; Beach et al., 2010; Del Tredici et al., 2010; Goedert et al., 2013). Here, SNCA is linked to Parkinson disease.