Previous reports have shown that TBX15 expression can be used as a prognostic marker for HCC (Morine et al., 2020), and HBB has been reported to play a key role in prostate cancer differentiation and in a variety of important biological pathways (e.g., iron metabolism) (Chen and Sun, 2021; Lin et al., 2021). Here, HBB is linked to hepatocellular carcinoma.