Based on a large number of retrospective publications, the cIMPACT Working Committee concluded that amplification of epidermal growth factor receptor (EGFR) gene, and/or increase of whole chromosome 7 with loss of whole chromosome 10 (+7/−10) and/or mutation of TERT promoter are highly specific indicators for poor prognosis of IDH wild-type diffuse astrocytoma (Wijnenga et al., 2017). Here, EGFR is linked to diffuse astrocytoma.