Several studies have reported the role of OPN in inflammation and fibrosis regulation in human aortic aneurysm disease and animal models (Bruemmer et al., 2003; Golledge et al., 2007; Zheng et al., 2012; Fan et al., 2019), however, the structural subtype or domain of OPN that participates in or promotes the progress of AAA formation remains to be determined. Here, SPP1 is linked to aortic aneurysm.