Herein, we showed that the expression of pyroptosis-related inflammatory factors such as NLRP3, pro-Caspase-1, GSDMD, ASC, IL-1β, and IL-18 were markedly higher in the Ang II group than the control group, whereas anti-OPN-N antibody attenuated this effect, thereby providing evidence supporting the causal link between OPN-N and pyroptosis-related inflammatory factors (e.g., NLRP3, pro-Caspase-1, IL-1β, and IL-18), and that OPN-N is a pro-inflammatory cytokine which stimulates pyroptosis and inflammation in Ang II-induced AAA mouse model. Here, PYCARD is linked to triple-A syndrome.