IL18 and triple-A syndrome: Usui et al. (2015) found that in Ang II induced AAA model, while knockdown of NLRP3, ASC and Caspase-1 genes can reduce the incidence and severity and the initial inflammatory responses of AAA. Several studies have suggested that activated NLRP3 inflammasome and GSDMD promote the release of pro-inflammatory factors such as IL-1β and IL-18, thereby inducing cell pyroptosis (Lamkanfi and Dixit, 2012; Strowig et al., 2012; Liu et al., 2016; Takahashi, 2021).