CASP1 and triple-A syndrome: Pyroptosis is an inflammatory cell death process induced by the activation of Caspase-1, which is activated by the NLRP3 inflammasome (Miao et al., 2010) which in turn has been shown to play an important role during the initial inflammatory response to AAA formation and is a potential therapeutic target against AAA (Sun et al., 2015; Usui et al., 2015; Takahashi, 2021).