SPP1 and Myocardial fibrosis: A functional serine-valine-valine-tyrosine-glutamate-leucine-arginine (SVVYGLR) motif of the OPN-N fragment attributes to the OPN-N proinflammatory property (Sharony et al., 2010) and enhancements of the myocardial fibrosis in the rat model of myocardial fibrosis (Uchinaka et al., 2015).