PFN1 and amyotrophic lateral sclerosis: One potential mechanism via monomeric PFN1 mutants could be the regulation of microtubule dynamics: unlike wildtype PFN1, four ALS PFN1 mutants (C71G, M114T, E117G, G118V) are unable to accelerate the growth of microtubules in vitro and in N2A cells (Henty-Ridilla et al., 2017).