Also, the expression of ANXA3 which promotes angiogenesis, drug resistance, and stemness in HCC (Tong et al., 2015, 2018), and the expression of KLF4 which is one of the Yamanaka factors that also regulates liver cancer stem cell plasticity (Karagonlar et al., 2020), increased upon regorafenib treatment (Figure 3B). Here, KLF4 is linked to hepatocellular carcinoma.