Also, the expression of ANXA3 which promotes angiogenesis, drug resistance, and stemness in HCC (Tong et al., 2015, 2018), and the expression of KLF4 which is one of the Yamanaka factors that also regulates liver cancer stem cell plasticity (Karagonlar et al., 2020), increased upon regorafenib treatment (Figure 3B). This evidence concerns the gene ANXA3 and liver cancer.