This feature could be explained, at least partly, by the fact that TRPML1 targets the apoptosis-like gene 2 (ALG-2) gene whose protein promotes caspase-3-independent cell death associated with glioblastoma progression and poor prognosis (Vergarajauregui et al., 2009; Zhang et al., 2017). The gene discussed is MCOLN1; the disease is glioblastoma.