In vitro, cannabidiol inhibits migration (Vaccani et al., 2005) and induces apoptosis in human glioma cells (Massi et al., 2004, 2006; Solinas et al., 2013), while it increases chemotherapeutic drug uptake and parallelly potentiates the cytotoxic activity of chemotherapeutic agents in a TRPV2-dependent manner in human glioma cells (Nabissi et al., 2013). This evidence concerns the gene TRPV2 and glioma.