TRPM8 was first identified in prostate carcinoma (Tsavaler et al., 2001) and then in a number of other cancer types (Liu et al., 2014; Yee et al., 2014; Yu et al., 2014); it has been more recently shown to be upregulated in glioblastoma compared to normal brain tissue (Alptekin et al., 2015; Zeng et al., 2019), while TRPM8 expression is highly heterogeneous in human glioblastoma specimens as well as in established cell lines (Klumpp et al., 2017). Here, TRPM8 is linked to cancer.