Although in most subgroups HAS did not show a difference in prognosis from SRC, in some subgroups of indicators suggesting an advanced stage of the tumor (T stage 4a & 4b, N stage 3a & 3b, with cancer nodules, serum CEA higher than the normal value, and serum CA199 higher than the normal value), HAS had a worse overall survival than SRC. Here, SRC is linked to neoplasm.