Although further research is necessary to clarify the underlying mechanism, the partners of hD53 were identified by proteomics as an important complement to the limited research of TPD52L1. YWHAG is an oncogene that encodes the 14-3-3γ protein and consistent with the expression pattern of TPD52L1 during the mucosal adenoma-carcinoma sequence. This evidence concerns the gene YWHAG and carcinoma.