Most DEGs in the brown module were involved in tumor progression or metastasis (module membership >0, cor = 0.83, p < 2.2e-16), including NOTCH3, VEGFA, SNAL1, TGFBR1, and MMP14 (Figure 3A), thereby confirming the correlation of some DEGs with phenotypes. Here, MMP14 is linked to neoplasm.