The proteasome, cell cycle, and translation activities, as well as the Wnt, NOTCH, and Myc pathways were activated early during normal to adenoma transition, whereas the MAPK, Src, JAK-STAT, EMT, p53, and TGFB1 pathways were activated late during adenoma to carcinomas transition (Figure 1B and Table S5). Here, TP53 is linked to adenoma.