GO analysis revealed that genes in cluster 5, which were monotonously downregulated during the adenoma-carcinoma sequence, were associated with the BPs of metabolism, including beta oxidation of fatty acids, the oxidation−reduction process, response to glucose, xenobiotic metabolism, the insulin receptor signaling pathway, tyrosine catabolism, and the cell surface receptor signaling pathway (Figure 2E). The gene discussed is INSR; the disease is carcinoma.