Most of these 70 proteins were slightly up-regulated along with TPD52L1 during the formation of CRC, and the expression patterns of 10 differential genes are consistent with TPD52L1 (TPD52L1, DNAJB6, YWHAG, NUP07, NUP93, XPOT, MAD2L1, CTPS1, SLC7A5, and MYO1B; Figure 6A). The gene discussed is MAD2L1; the disease is colorectal carcinoma.