SMPD3 and cancer: The genes associated with immune response (TNFRSF1A, CMKLR1, CTSG, CD22, SECTM1) had similar expression patterns in cluster 3 (Figure S4A), while those associated with the canonical cancer pathway (MMP14, NOTCH3, TGFB3, TGFBR1, VEGFA) share expression patterns with cluster 4 (Figure S4B) and those associated with metabolism (ACACB, GALNT12, MAOA, PLCD1, SMPD3) had similar expression patterns in cluster 5 (Figure S4C).