In hepatocellular carcinoma, the up-regulated expression of GPC3 was closely associated with malignant behavior and poor prognosis of tumors (51, 52); while in breast cancer, its over-expression not only inhibits tumor invasion and metastasis, but also was related to the decrease of cell viability and survivability, the increased homogeneous adhesion (50) along with the transformation of mesenchymal cells into epithelial cells (53). Here, GPC3 is linked to hepatocellular carcinoma.