In pancreatic cancer, the m6A eraser ALKBH5 was not only considered as a tumor-suppressor gene, which was involved in sensitizing pancreatic cancer cells to chemotherapy via regulating Wnt signaling, but also reported to prevent pancreatic cancer progression by posttranscriptional activation of PER1 in an YTHDF2-dependent manner (27, 40). This evidence concerns the gene PER1 and familial pancreatic carcinoma.