As shown in Figures 4E, F, the expression of VEGF was markedly upregulated in HUVECs incubated with lymphoma cell-secreted exosomes; however, VEGF expression in HUVECs was markedly downregulated by the exosomes isolated from HHT/curcumin combination-treated Raji cells (Raji/combination exosomes) compared to those isolated from control Raji cells (All P < 0.01). Here, VEGFA is linked to lymphoma.