AFP and hepatocellular carcinoma: On one hand, according to TCGA, we found that LINC01667 had an AUC of >0.92, and based on the local cohort, the AUC was >0.81, with the value being superior to that of alpha-fetoprotein (AFP, 41%–65% sensitivity and 80%–94% specificity for elevated serum AFP levels of >20 ng/mL in diagnosing HCC) (24), one of the most common diagnostic biomarkers for HCC.