Further multivariate survival analysis displayed that tumor stage (HR 3.812, 95% CI [2.460–5.907], P < 0.001), grade (HR 2.187, 95% CI [1.526–3.133], P < 0.001), metastasis (HR 2.894, 95% CI [1.585–5.282], P = 0.001) and p-mTOR (HR 1.733, 95% CI [1.037–2.897], P = 0.036), were all recognized as independent predictors for CSS in patients with ccRCC (Table 2), while tumor size, mTOR expression, patients’ age, or sex were not identified as prognostic factors (P = 0.134, P = 0.122, P = 0.472, P = 0.170, respectively, Table 2). This evidence concerns the gene MTOR and nonpapillary renal cell carcinoma.