MTOR and nonpapillary renal cell carcinoma: Darwish evaluated the prognostic significance of multiple biomarkers in mTOR pathway components, including p-mTOR in 419 patients with ccRCC, and found a negative correlation between the marker score of mTOR pathway components and the recurrence-free survival (RFS) and CSS in nonmetastatic ccRCC patients (Darwish et al., 2013).