Subsequently IHC analysis demonstrated that p-mTOR expression was positively correlated with tumor size, pathological stage, and metastasis status (P = 0.001, P < 0.001, P = 0.003, respectively), and negatively correlated with CSS (P < 0.001), which implied elevated p-mTOR was significantly correlated with the aggressiveness of ccRCC (Rausch et al., 2019). The gene discussed is MTOR; the disease is neoplasm.