CD274 and neoplasm: Briefly, mTOR could regulate the expression of cytokines/chemokines, including interleukin-10 (IL-10) and transforming growth factor-β (TGF-β), and/or membrane receptors, such as cytotoxic T-Lymphocyte protein 4 (CTLA-4), PD-L1 and PD-1, to modulate tumor immune cells (Irelli et al., 2019).