NEDD4 is shown to be overexpressed in various types of human cancers including gastric cancer (Kim et al., 2008; Sun et al., 2014; Reichert-Penetrat et al., 1998), colorectal cancer (Kim et al., 2008), breast cancer (Kim et al., 2008), non-small-cell lung carcinoma (Amodio et al., 2010; Shao et al., 2018), and hepatocellular carcinoma (Hang et al., 2016; Huang et al., 2017). Here, NEDD4 is linked to hepatocellular carcinoma.