Chi-square test showed that lower levels of NEDD4L were significantly associated with adverse prognostic features, including ccRCC with higher T stages (OR = 0.456 (0.322−0.646) for T1 vs. T2/3/4, P < 0.001), M stage (OR = 0.530 (0.342−0.821) for M0 vs. M1/X, P = 0.004), OSG tumor stage (OR = 0.429 (0.299−0.615) for stage I/II vs. stage III/IV, P < 0.001), histological grade (OR = 0.456 (0.321−0.647) for G1/2 vs. G3/4, P < 0.001) (Table 2). The gene discussed is NEDD4L; the disease is neoplasm.