Decreased NEDD4L expression has been found in colorectal cancer (Tanksley, Chen & Coffey, 2013), gastric cancer (Jiang et al., 2019), ovarian cancer (Yang et al., 2015), prostate cancer (Hu et al., 2009), and non-small cell lung cancer (Hu et al., 2009). This evidence concerns the gene NEDD4L and Familial prostate cancer.