In cancers, NEDD4, WWP1, WWP2, SMURF1, and SMURF2 have been shown to function as oncogenes, while NEDD4L acts as an antioncogene (Chen & Matesic, 2007; Tanksley, Chen & Coffey, 2013; Zhao et al., 2015). The gene discussed is NEDD4L; the disease is cancer.