Endothelial dysfunction biomarkers, such as thrombomodulin, von Willebrand factor (vWF), angiopoietin 2, and PAI-1, are frequently increased in patients with COVID-19 compared to healthy persons and seem to have prognostic significance, being associated with more severe forms of the disease and high mortality [23, 24]. Here, VWF is linked to endothelial dysfunction.