Studies have found that leptin activates the cluster of differentiation 14 (CD14) expression via the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway [10], and the pathological activation of the CD14/TLR4 pathway is involved in the development of various inflammatory and rheumatic diseases. Here, JAK2 is linked to rheumatic disorder.