TNF and cancer: In addition, KEGG pathway analysis showed that these genes were mainly involved in complement and coagulation cascades, fluid shear stress and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, osteoclast differentiation, malaria, glycerolipid metabolism, apelin signaling pathway, colorectal cancer, fat digestion and absorption, MAPK signaling pathway, human T-cell leukemia virus 1 infection, choline metabolism in cancer, Chagas disease, and TNF signaling pathway (p < 0.05; Figure 7(e)).