M1 phenotype microglia can produce a variety of mediators, including inducible nitric oxide synthase (Nos2), C-X-C motif chemokine 10 (Cxcl10, as known as IP10), tumor necrosis factor (Tnfα), and cyclooxygenase-2 (Cox2) to induce oxidative stress, inflammation, and necroptosis after stroke [6]. Here, TNF is linked to Stroke.