It was reported that cisplatin increased the expression of proinflammatory cytokine TNF-α, which induced an exogenous apoptotic pathway through its tumor necrosis factor receptor 1 (TNFR1) [47], and TNF-α can activate proinflammatory cytokines and chemokines such as NF-κB and trigger oxidative stress, which ultimately aggravates kidney damage [48]. This evidence concerns the gene NFKB1 and Nephropathy.