Hypergeometric distribution was used for calculating the target gene enrichment pathway analysis (Figure 7), which showed that the main signaling pathways involving the target genes of the differentially expressed miRNAs included pathway in cancer, microRNAs in cancer, Ras signaling pathway, PI3K-Akt signaling pathway, cAMP signaling pathway, MAPK signaling pathway, Apelin signaling pathway, cGMP-PKG signaling pathway, and Wnt signaling pathway. Here, APLN is linked to cancer.