ERBB2 and breast carcinoma: Therefore, Chang et al. studied the antiproliferation effects of 7 anthraquinone derivatives on human breast cancer cells and found that only rhein had antiproliferation and apoptosis effects on both MCF-7 (MCF-7/HER2) cells overexpressing HER2 and the control vector MCF-7 (MCF-7/VEC) cells.