A variety of reasons have been proved to be implicated in the pathogenesis of liver fibrosis, such as infections, viruses, drugs, genetics, and chemical poisons, which may lead to inflammation and necrosis of liver cells, stimulate the transformation of silent hepatic stellate cells (HSCs) into muscle fibroblasts (MFB), and release a large amount of α-SMA concurrently. Here, ACTA1 is linked to Hepatic fibrosis.