IL18R1 and inflammatory bowel disease: The KEGG pathway analysis further highlighted the alteration of pathways related to immune and inflammatory responses, including cytokine-cytokine receptor interaction, inflammatory bowel disease (IBD), IL-17 signaling pathway, leukocyte transendothelial migration, Toll-like receptor signaling pathway, and intestinal immune network for IgA production (Figure 1C and Table 2).