More importantly, mesalazine treatment reversed the suppressive effect of immune responsive genes, including chemokine (C–X–C motif) ligand (CXCL3), chemokine (C–C motif) ligand (CCL11 and CCL21), chemokine receptor (CXCR2), and colony-stimulating factor (CSF3) in the DSS-induced colitis model (Table 6). This evidence concerns the gene CSF2 and colitis.