In contrast, in subjects with NFSS, we found variants in multiple genes that have been found to cause monogenic short stature, including BRF1 (Cerebellofaciodental Syndrome) (Jee et al., 2017), QRICH1 (Ververi-Brady Syndrome) (Lui et al., 2019), FBN1 (acromelic dysplasia), HUWE1 (X-linked mental retardation syndrome), SRCAP (Floating-Harbor syndrome), ACAN (short stature and advanced bone age) (Tatsi et al., 2017), ZEB (Mowat-Wilson Syndrome), and CUL7 (3-M syndrome). Here, ACAN is linked to 3M syndrome.