VDR and musculoskeletal system disorder: Nevertheless, some VDR polymorphisms have been linked to some musculoskeletal diseases, such as idiopathic scoliosis susceptibility or curve severity, herniation and spinal tissues degeneration and rheumatoid arthritis (Saad et al., 2015; Di Spigna et al., 2016; Vieira et al., 2018; Li et al., 2019).