Second, prior to this study, only the tumor suppressor function of SEC23A has been reported in preclinical studies when SEC23A was the target gene of miRNAs (Boyadjiev et al., 2006; Korpal et al., 2011; Szczyrba et al., 2011; Li et al., 2016; Sun et al., 2018, 2020). This evidence concerns the gene SEC23A and neoplasm.