Similarly, a total of 18 non-paclitaxel resistance-specific genes (DIO2, PLEKHN1, DGAT2, CD59, CCBE1, USP43, ZBED2, SLC6A4, BRCC3, ZFYVE21, L1CAM, SQRDL, NEBL, AMOTL1, ARNTL2, TMEM45B, LRRC20, and ADAMTSL4) were obtained from the intersection of the genes with low expression in ESCC tumor samples, low expression in the paclitaxel resistance cell lines, and negatively associated with ESCC tumor status (Figure 4A). This evidence concerns the gene PLEKHN1 and esophageal squamous cell carcinoma.