COL1A1 and esophageal squamous cell carcinoma: Based on the results of functional enrichment analysis, we speculate that COL1A1 may regulate the sensitivity of ESCC to paclitaxel through ECM-related pathways, which is corroborated by the findings that the α1 chain coded by COL1A1 is an essential component of the ECM (Rousseau et al., 2014).