As shown in Figures 6A,B, a total of eight key genes associated with non-paclitaxel resistance were obtained by LASSO analysis: CD59, L1CAM, BRCC3, PLEKHN1, AMOTL1, TMEM45B, CCBE1, and USP43. The expression levels of CCBE1, PLEKHN1, and USP43 were significantly different in the ESCC tumor group compared with the normal group (Figure 6C). This evidence concerns the gene USP43 and neoplasm.