Similarly, a total of 18 non-paclitaxel resistance-specific genes (DIO2, PLEKHN1, DGAT2, CD59, CCBE1, USP43, ZBED2, SLC6A4, BRCC3, ZFYVE21, L1CAM, SQRDL, NEBL, AMOTL1, ARNTL2, TMEM45B, LRRC20, and ADAMTSL4) were obtained from the intersection of the genes with low expression in ESCC tumor samples, low expression in the paclitaxel resistance cell lines, and negatively associated with ESCC tumor status (Figure 4A). The gene discussed is BRCC3; the disease is esophageal squamous cell carcinoma.