As shown in Figures 6A,B, a total of eight key genes associated with non-paclitaxel resistance were obtained by LASSO analysis: CD59, L1CAM, BRCC3, PLEKHN1, AMOTL1, TMEM45B, CCBE1, and USP43. The expression levels of CCBE1, PLEKHN1, and USP43 were significantly different in the ESCC tumor group compared with the normal group (Figure 6C). The gene discussed is L1CAM; the disease is neoplasm.