According to a molecular epidemiology survey, glucose-6-phosphate dehydrogenase (G6PD) deficiency has an anti-malaria effect and we found that the G6PD Mahidol 487G>A variant protects against uncomplicated Plasmodium vivax (P.vivax) infection and reduces disease severity in previous study (6). This evidence concerns the gene G6PD and hyperinsulinemic hypoglycemia, familial, 4.