As a future direction, we plan to investigate interactions between HIF and other signaling pathways identified in the pathogenesis of sarcoidosis as mTOR, NLRP3 inflammasome, JAK/STAT, or heat shock proteins (49, 68, 69), already known to interfere with the HIF/hypoxia pathway (22, 70–72). This evidence concerns the gene MTOR and sarcoidosis.