For example, ILD manifests and is the leading cause of mortality in Systemic-Sclerosis, an extensively studied autoimmune disease with anti-nuclear autoantibodies (ANA) (anti-centromere antibodies, anti-topoisomerase I antibodies, and anti-RNA polymerase antibodies) and anti-endothelial cell antibodies (AECA) in greater than 90% of patients with potential pathogenic roles (18). This evidence concerns the gene BTG3 and interstitial lung disease.